医药前沿杂志

摘要：目的 评估呼出气一氧化氮（FeNO）在支气管哮喘管理中的价值。方法 选取未规范治疗的哮喘患者30例，给予布地奈德福莫特罗粉吸入剂治疗8周，检测治疗前后的FeNO、肺功能、ACT评分、血清总IgE及诱导痰。同期选取30例健康志愿者，检测FeNO。结果 哮喘组治疗后FeNO水平较治疗前显著降低（34.50±11.85 vs.72.93±21.88 P<0.01），治疗前后的FeNO水平均显著高于健康对照组（72.93±21.88 vs.9.87±2.84；34.50±11.85 vs.9.87±2.84,P=0.000），治疗后的FEV1%pred及ACT评分均显著高于治疗前（73.34±6.83 vs.71.45±7.83； 22.70±2.00 vs.19.83±3.12, P=0.000），治疗后血清总IgE、诱导痰Eos%均显著低于治疗前（154.17±37.55 vs.203.17±51.20；7.22±2.07 vs.9.56±2.33,P=0.000）。治疗前后的FeNO水平与FEV1%pred、ACT评分呈显著负相关（r值分别为-0.931，-0.973，P<0.01）,与血总IgE、诱导痰Eos%呈显著正相关（r值分别为0.766，0.756，P<0.01）。结论 FeNO是一种评估气道炎症的可行性指标，有助于评估哮喘的控制情况及指导治疗。
关键词：呼出气一氧化氮（FeNO）；支气管哮喘；管理
The Use of Fractional Exhaled Nitric Oxide in the nanagement of Asthma
Feng Jia-gang
(Dept．2 of Respiratory Medicine，The first Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China)
Abstract：0bjective To evaluate the Fractional exhaled nitric oxide(FeNO)reference values in asthma management．Methods  Thirty asthmatic patients without standard medication treatment were recruited. Given budesonide formoterol inhalation powder for 8 weeks. to evaluate the changes of FeNO level, pulmonary functions,ACT scores,total serum IgE and Eosinophilic granulocyte counts in induced sputum．At the same time，Thirty healthy people were recruited as control group and their FeNO 1evels were tested．Results After treatment FeNO levels significantly reduced than before the treatment of asthma group（34.50±11.85 vs.72.93±21.88 P<0.01）, FeNO levels before and after treatment were significantly higher than the control group（72.93±21.88 vs. 9.87±2.84;34.50±11.85 vs. 9.87±2.84,P=0.000）,the FEV1% pred and ACT scores afte treatment were significantly higher than before treatment（73.34±6.83 vs.71.45±7.83; 22.70±2.00 vs.19.83±3.12, P=0.000）; After treatment, serum total IgE, sputum Eos% were significantly lower than before treatment (154.17 ± 37.55 vs. 203.17 ± 51.20; 7.22 ± 2.07 vs. 9.56 ± 2.33, P = 0.000). FeNO levels before and after treatment with FEV1% pred, ACT score was a significant negative correlation (r values were -0.931, -0.973, P <0.01). FeNO levels before and after treatment with serum total IgE and sputum Eos% was a significant positive correlation (r values were 0.766,0.756, P <0.01). Conclusions FeNO is an assessment of the feasibility indicator of airway inflammation,and Conducive to assess control of asthma and guide treatment.

 [Key words] fractional exhaled nitric oxide(FeNO)；bronchial asthma；asthma management

来源：www.chinajj.org