医药前沿杂志

摘要：硝呋太尔系二十世纪六十年代意大利普利化工公司开发的抗菌药物，已在许多国家上市多年。现合成方法大概有三种，1、采用甲硫醇气体进行肼解、环合、精制，该工艺收率高，约78.5%，污染少。2、直接甲硫醇钠、环氧氯丙烷进行肼解、环合、精制，该工艺污染大，环保压力大，收率也不高，约50%收率。3、自己生产甲硫醇，在采用第1条路线，该过程对设备要求高，投资大，而市场有销售的甲硫醇，不建议采用。本论文主要是讨论第一条路线。
关键词：硝呋太尔；合成：工艺

Abstract: Infuriately Department of the sixties of the 20th century Italian Pull chemical companies to develop antimicrobial drugs has been in many countries listed for many years. This synthetic method about three, 1, the methanethiol gas hydrazine solution, stylization, refining, the process yield high, about 78.5% and less polluted. 2, direct sodium methyl mercantile, epoxy chloropropane hydrazine solution, stylization, refining, the process of pollution, environmental pressure, yield is not high, about 50% yield. 3, their production of a thinly, in the use of second routes, the process requires high equipment, large investment, and the market has sales of a thinly, do not recommend the use of. This paper is mainly to discuss the first route.

来源:医药前沿唯一官网